The Use of Topical Aminoglycosides as an Effective Pull in "Prime and Pull" Vaccine Strategy

Gopinath S, Lu P, Iwasaki A. Cutting Edge: J Immunol. 2020 Mar 2. PMID: 32122994

Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner

Gopinath S, Kim MV, Rakib T, Wong PW, van Zandt M, Barry NA, Kaisho T, Goodman AL and Iwasaki I. Nature Microbiology. 2018 May;3(5):611-621

Highlighted in News and Views, Cohen J, New activities for old antibiotics. Nature Microbiology. 2018. 3, 531–532.

This Week in Microbiology (TWiM 175) Neomycin is antiviral

Some antibiotics rev up the host immune response to viruses, The Scientist

CD301b+ dendritic cells are required for tissue-resident memory CD8 T cell activation.

Shin H, Kumamoto Y, Gopinath S, Iwasaki A. Nature communications 2016 Nov 9;7:13346

Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling

Chernyavskaya Y, Mudbhary R, Zhang C, Tokarz D, Jacob V, Gopinath S, Sun X, Wang S, Magnani E, Madakashira BP, Yoder JA, Hoshida Y, Sadler KC. Development. 2017 Aug 15;144(16):2925-2939

O-linked sugars sound the alarm

Gopinath S, Kumamoto Y, Iwasaki A. . News and Views, Nature immunology. 2016 Jan 19;17 (2), 119-120

Coordinate actions of innate immune responses oppose adaptive immunity during Salmonella infection

Hotson AN*, Gopinath S*, Nicolau M, Khasanova A, Finck R, Monack DM, Nolan GP. Science Signaling. 2016 Jan 12; 9(410) (* indicates co-first authorship)

Cervicovaginal microbiota: simple is better

Gopinath S, Iwasaki A. Previews, Immunity. 2015 May 19; 42(5):790-1.

The role of disease-associated tolerance in infectious superspreaders

Gopinath S, Lichtman JS, Bouley DM, Elias JE, Monack DM. PNAS. 2014 Nov 4; 111 (44):15780-5.

Highlighted in Nature Research Highlights. Leavy O. Infectious disease: The tolerance of superspreaders. Nature Reviews Immunology. 2014. 14, 776–777.

The 20% Who Spread Most Disease, Wall Street Journal

The systemic immune state of super-shedder mice is characterized by a unique neutrophil-dependent suppression of TH1 responses

Gopinath S*, Hotson AN*, Johns J, Nolan GA, Monack DM. PLoS Pathogens. 2013; 9(6) (* indicates co-first authorship)

Microbiota-liberated mucosal sugars facilitate enteric pathogen post-antibiotic emergence.

Ng KM, Ferreyra J, Higginbottom S, Lynch JB, Gopinath S, Naidu N, Choudhary B, Weiner BC, Monack DM, Sonnenburg JL. Nature. 2013 Oct 3;502(7469): 96-9.

The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the Interferon-γ Locus.

Gomez JA, Wapinski OL, Yang YW, Bureau JF, Gopinath S, Monack DM, Chang HY, Brahic M, Kirkegaard K. Cell. Feb 2013;14;152 (4): 743-54.

Shedding light on Salmonella carriers

Gopinath S, Carden S, Monack D. Trends in Microbiology. 2012 Jul;20 (7):320-7.

Salmonella's long-term relationship with its host

Ruby T, McLaughlin L, Gopinath S, Monack D. FEMS Microbiology Review. 2012 May; 36 (3):600-15.

The Salmonella SPI2 effector SseI mediates long-term systemic infection by modulating host cell migration

McLaughlin LM, Govoni GR, Gerke C, Gopinath S, Peng K, Laidlaw G, Chien YH, Jeong HW, Li Z, Brown MD, Sacks DB, Monack DM. PLoS Pathogens. 2009 Nov;5(11):e1000671.